Basic Information
VIS ID
TVIS44028790
Fusion event
HTLV-1-PIK3CD integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
NCBI36/hg18
Start
9638740/9656095 (Hg38)
End
9638740/9656095 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
PIK3CD
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-30a-5p ; hsa-mir-10b-5p ; hsa-mir-125b-5p ; hsa-mir-663a ; hsa-mir-199a-5p ; hsa-mir-101-3p ; hsa-mir-25-3p ; hsa-mir-25-5p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4459 ; hsa-mir-500a-3p ; hsa-mir-582-5p ; hsa-mir-6087 ; hsa-mir-655-5p ; hsa-mir-658 ; hsa-mir-6807-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-4433a-3p ; hsa-mir-4690-3p ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-544b ; hsa-mir-5685 ; hsa-mir-6765-3p ; hsa-mir-7162-3p
Nearest miRNA
hsa-mir-12136/Upstream/504318; hsa-mir-101-1/Downstream/311286;
Nearest TSS
ENST00000473358/Upstream/1509; ENST00000484851/Downstream/31460;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3152, chr1-CpG: 102/Downstream/33142
Upstream sequence
cTTCCTATTACATTCTGAGCACAGGGGGAGTGATCAGAGTGAAGGGTGTGGCATTTCCAAAGTGGTATTTCGGTTGGCTTCTGTTTCACTCATATTGGGG
Downstream sequence
GAAATTGCTTCCACTTAGAGAAAATGCCGGAAGAGTGGGCGGTGCCAGGAGTAGGGTGGGGGAGGAGGAGATGCAGAAAGGGATAGACCTATTTGGGATT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate