Basic Information
VIS ID
TVIS44028801
Fusion event
HTLV-1-EXT2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
NCBI36/hg18
Start
44115621/44137495 (Hg38)
End
44115621/44137495 (Hg38)
Orient
+
Location type
Intronic
Target gene
EXT2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-4709-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3185 ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-4632-5p ; hsa-mir-6735-5p ; hsa-mir-4436b-3p ; hsa-mir-548p ; hsa-mir-6753-5p
Nearest miRNA
hsa-mir-129-2/Upstream/556012; hsa-let-7a-2/Downstream/1554209;
Nearest TSS
ENST00000527297/Upstream/7452; ENST00000528159/Downstream/69370;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/41051, chr11-CpG: 19/Downstream/165830
Nearest cancer related gene
EXT2(TSG, No orient, 0)
Upstream sequence
TGTCTGTGGGCAAATACAATTGAGTAGTATGTGGATCTTAGTCTGTATAGGTCACCCGTTTTACTGTGATGCCAGTTTTAATTGGTTTGGTGACTTTTCC
Downstream sequence
AAGAGCAGCTCACCAAAGCATTCTTTAAATTTAGGAGAATTAGGGTCCCTAATTTCATAATGCAAATCTAAATTCTCACAGTCTAGATGGAGAGACCATA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate