Basic Information
VIS ID
TVIS44028834
Fusion event
HTLV-1-ZBTB7C integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
NCBI36/hg18
Start
44157480/48377111 (Hg38)
End
44157480/48377111 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/996546; hsa-mir-122/Downstream/293489;
Nearest TSS
ENST00000575820/Upstream/1486; ENST00000591412/Downstream/32181;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/214970, chr18-CpG: 262/Downstream/30971
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
TGAGAAAGAGGGTTCCCAGAAAGAATCCAGGGGCTGAAAGCAGGGCTGAGATCAAGCCCTCAGGGACTCAGCCTGGGCCCCCACACCAGGCCTCCTGCAG
Downstream sequence
GTTCCAGAGGATGGGGGAGGCGATGCTCTGGCAACCCCACTCCACCCCCCAACAGAGCATCATTCCACAGACCACTTTGTTCTGtttgttcatgctgcaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate