Basic Information
VIS ID
TVIS44028839
Fusion event
HTLV-1-STAMBPL1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
NCBI36/hg18
Start
90634103/88884366 (Hg38)
End
90634103/88884366 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
STAMBPL1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-941 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4633-5p ; hsa-mir-766-3p ; hsa-mir-885-5p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-6868-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6837-3p ; hsa-mir-4778-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-548p ; hsa-mir-5197-5p
Nearest miRNA
hsa-mir-1265/Upstream/1380412; hsa-mir-107/Downstream/178969;
Nearest TSS
ENST00000439456/Upstream/2283; ENST00000371924/Downstream/16709;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3500, chr10-CpG: 68/Downstream/106170
Upstream sequence
TACCAAGTATTTATTTGACAAGTAGGCTCTTAAGCACTTGAACAGAAGTGAAAAGCGGGTTTCCTCCATGTCATATTAAGGCCCTTGAAAGGTGGGGGTG
Downstream sequence
GAATTTTGATTTGAGGTGGTAGCCAATTGTAGGTTCCTTGAAAGGGAGCAAGTGAGGAAAGCATGTTGTCAGAAGAACACTTTGGCAGTTGGGTGGAGAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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