Basic Information
VIS ID
TVIS44028898
Fusion event
HTLV-1-METTL6 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
NCBI36/hg18
Start
15431154/15414643 (Hg38)
End
15431154/15414643 (Hg38)
Orient
-
Location type
Intronic
Target gene
METTL6
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-7109-5p ; hsa-mir-6085 ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-6824-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-765 ; hsa-mir-4784 ; hsa-mir-4731-5p ; hsa-mir-3150b-3p ; hsa-mir-637 ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-12127/Upstream/5020081; hsa-let-7g/Downstream/81596;
Nearest TSS
ENST00000440867/Upstream/15152; ENST00000449565/Downstream/1217;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/81941, chr3-CpG: 46/Downstream/12782
Upstream sequence
gaggtttcaccatgttggccaggctagtctcgaactcctgacctcaagtaatttgcccacctcagtctcccaaagttgggattacaggcgtgagccacct
Downstream sequence
cgctcgtccCTGAAGACAATTCTTGAGTACCTCCAAGAGCACCCTGGAATGTCCAGTGTCACAGGATTAAAATgttagagaccaacctgggcaatatagt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate