Basic Information
VIS ID
TVIS44028902
Fusion event
HTLV-1-POLG integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
NCBI36/hg18
Start
87672909/89328674 (Hg38)
End
87672909/89328674 (Hg38)
Orient
-
Location type
Intronic
Target gene
POLG
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-296-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-221-3p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-6780a-3p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-505-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-4778-3p ; hsa-mir-676-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-877-3p ; hsa-mir-3065-5p ; hsa-mir-127-5p ; hsa-mir-3928-5p ; hsa-mir-6806-3p
Nearest miRNA
hsa-mir-10393/Upstream/1864; hsa-mir-1302-10/Downstream/39343;
Nearest TSS
ENST00000557528/Upstream/1338; ENST00000569473/Downstream/38;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/84214, chr15-CpG: 51/Downstream/4485
Upstream sequence
TCCCATTACCACCACCAGCTCTCAGGGTCAGGCCTGGCAGCTGCATCTCCCCAAGTGCAGCTAGGGGTGTGCCACAGCCCATGTCCCCAGAGCCCCCTCC
Downstream sequence
AGCACCATACCTGGAAGTTCTCACGAATGTCCTTCATGGTGCCCTTCACAAACAGTTCTCGAGGCTCCTTCTCTAAGGGAGGCCCCCCTACATAAAGTCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate