Basic Information
VIS ID
TVIS44028924
Fusion event
HTLV-1-MTAP integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
NCBI36/hg18
Start
21830904/21840905 (Hg38)
End
21830904/21840905 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
MTAP
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-155-5p ; hsa-mir-34a-5p ; hsa-mir-5585-3p ; hsa-mir-421 ; hsa-mir-125a-3p ; hsa-mir-4709-5p ; hsa-mir-577 ; hsa-mir-552-3p ; hsa-mir-4662a-3p ; hsa-mir-6868-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-4778-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4717-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-891a-3p ; hsa-mir-143-5p ; hsa-mir-550a-3p ; hsa-mir-4430 ; hsa-mir-200c-5p ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-550b-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-5693 ; hsa-mir-3664-5p ; hsa-mir-514a-5p ; hsa-mir-4714-5p
Nearest miRNA
hsa-mir-101-2/Upstream/328720; hsa-let-7a-1/Downstream/7022721;
Nearest TSS
ENST00000422679/Upstream/37627; ENST00000581962/Downstream/13819;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/37923, chr9-CpG: 51/Downstream/124192
Nearest cancer related gene
MTAP(TSG, No orient, 0)
Upstream sequence
gctgctgatggagtgggcaggtgggaaggggtgaggtccaaaggccatgcttgctttcccagtggggtagctcacagcctggggcaaggtctgagcaggg
Downstream sequence
cactgcaggagtgagactagcctcaccaactgcatagtagctggatgaggcctcttgctgctggctctcccccactaccctggtaaagtttatgatacag
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate