Basic Information
VIS ID
TVIS44028955
Fusion event
HTLV-1-JAKMIP3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
NCBI36/hg18
Start
133711940/132048446 (Hg38)
End
133711940/132048446 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
JAKMIP3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3663-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-660-3p ; hsa-mir-1306-5p ; hsa-mir-1228-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6736-3p ; hsa-mir-149-3p ; hsa-mir-3141 ; hsa-mir-3153 ; hsa-mir-4728-5p ; hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-6768-3p ; hsa-mir-6783-5p ; hsa-mir-6785-5p ; hsa-mir-6883-5p
Nearest miRNA
hsa-mir-107/Upstream/1085778; hsa-mir-202/Downstream/1199065;
Nearest TSS
ENST00000439456/Upstream/66433; ENST00000298622/Downstream/56225;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/526, chr10-CpG: 23/Downstream/17055
Upstream sequence
tcgggctcccaggcactggcctgtcgtgcttttccactccctgcgatttgctgtaaggaaaggctgttccttctccccatttgtctgtttgtttatgtca
Downstream sequence
gtagggacacgtggatacttattccatgggctaaaatccggtaatgacaatatttgttttgttaaacaaatcactccagctttgagcttcaggagctcct
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate