Basic Information
VIS ID
TVIS44028961
Fusion event
HTLV-1-TBC1D5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
NCBI36/hg18
Start
17425481/17408985 (Hg38)
End
17425481/17408985 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D5
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-493-5p ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-361-3p ; hsa-mir-329-5p ; hsa-mir-6779-3p
Nearest miRNA
hsa-mir-12127/Upstream/475725; hsa-let-7g/Downstream/1905863;
Nearest TSS
ENST00000440867/Upstream/2265; ENST00000449613/Downstream/214928;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/523635, chr3-CpG: 58/Downstream/333585
Upstream sequence
CTGAAATCTTGTGGGGCTTTTTTCCCCATTTTAATCCATTTTTATTACCTAAAATATTCTAAATATGTCCTATTTCCAAGTAGTTACGCATATATACTGA
Downstream sequence
TATCTCATAATGTTCAAATTTATTGTCTAGTTTTTAGCAATATTCAAAGATGAGATTAGCAATCAGTACATTACAGGAGTAGaggcatacctcattttat
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate