Basic Information
VIS ID
TVIS44028962
Fusion event
HTLV-1-ROS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
117790864/117363008 (Hg38)
End
117790864/117363008 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10578788; hsa-mir-1202/Downstream/1706039;
Nearest TSS
ENST00000381078/Upstream/25668; ENST00000533950/Downstream/62847;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/91892, chr6-CpG: 113/Downstream/119326
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
TATAAAGAATATAAGACTTTTACCACTTATAATAAGATTGTAAACAACTTAACAATATTTCTcattccaggcagttgcagtatatttattacattcttaa
Downstream sequence
agatcttcaggagagaatattccatagatttcttcaggaacccatcctgataatttcagcacatctgactgacaggcaagacttccttatgttcaactca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate