Basic Information
VIS ID
TVIS44029055
Fusion event
HTLV-1-SDK1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
p22.2
Reference genome
NCBI36/hg18
Start
3625624/3619466 (Hg38)
End
3625624/3619466 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
SDK1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-625-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-3202 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-3179 ; hsa-mir-1252-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-6758-5p ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6780b-5p ; hsa-mir-4271 ; hsa-mir-4725-3p ; hsa-mir-6877-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4533 ; hsa-mir-6784-5p ; hsa-mir-6892-3p ; hsa-mir-6891-5p ; hsa-mir-6783-5p ; hsa-mir-3173-3p
Nearest miRNA
hsa-mir-339/Upstream/1092321; hsa-mir-10399/Downstream/1169099;
Nearest TSS
ENST00000635602/Upstream/317014; ENST00000478527/Downstream/24318;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/317365, chr7-CpG: 21/Downstream/494547
Upstream sequence
GAATAGATTTGAATATGTAATTAGAATGTGATTTACTATTCTGATATAGGTTGTACTTACACCTAGGAAGTCTATCATTATATTTGTAAAAGTAAGCCCA
Downstream sequence
TTAGTGAAATTATCAGTCAACAAAAACCTATGGTTACAGAGCAATGCCAATAACAGCTTTGGTATGATACATTTACTTTCCAAGGGCAACAGCCCTACCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate