Basic Information
VIS ID
TVIS44029116
Fusion event
HTLV-1-MDGA2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
NCBI36/hg18
Start
46834533/47295580 (Hg38)
End
46834533/47295580 (Hg38)
Orient
-
Location type
Intronic
Target gene
MDGA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-208a/Upstream/10343189; hsa-mir-1185-1/Downstream/465415;
Nearest TSS
ENST00000550708/Upstream/163742; ENST00000557531/Downstream/47536;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/643624, chr14-CpG: 186/Downstream/378650
Upstream sequence
ACATTTATTTGGGTGGAGAACATGAAAATCATATTTTCTAATTCATAGGGTAGATAAAAAATGTTTGAGGTCAACTGAGGAAATATTTTAAAACAACTAT
Downstream sequence
AAAGGAATGACCTGCTCATTTATATATCAAAATGTATTATAggccgggcgcagtggctcacaactgtaatcctagcactttgggaggctgaggtgggcga
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate