Basic Information
VIS ID
TVIS44029157
Fusion event
HTLV-1-SMC5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
NCBI36/hg18
Start
72154966/70350230 (Hg38)
End
72154966/70350230 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMC5
miRNAs that regulate target gene
hsa-mir-377-3p ; hsa-mir-4653-3p ; hsa-mir-216b-3p ; hsa-mir-4459 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6087 ; hsa-mir-1247-3p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-570-3p ; hsa-mir-28-3p ; hsa-mir-708-3p ; hsa-mir-7844-5p
Nearest miRNA
hsa-mir-101-2/Upstream/29116395; hsa-let-7a-1/Downstream/459745;
Nearest TSS
ENST00000422679/Upstream/3838; ENST00000436491/Downstream/64394;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/90882, chr9-CpG: 161/Downstream/62184
Upstream sequence
TGGAATTCGAATTAGAGTCAAATTTCGAAGTAGTACTCAACTGCATGAATTAACTCCTCATCATCAAAGTGGAGGTGAAAGAAGTGTTTCTACCATGTTA
Downstream sequence
TACTTGATGGCACTTCAGGAGCTAAATAGATGTCCATTCAGAGTAGTTGATGAAATCAATCAGGTATGGTGATTGTTCTGTTACTTGGATCTTCTTATAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate