VISDB - VIS Detail

Basic Information

VIS ID

TVIS44029178

Fusion event

HTLV-1-MGAT5 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr2

Cytoband

q21.2

Reference genome

NCBI36/hg18

Start

134756250/134282209 (Hg38)

End

134756250/134282209 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA2S

Target gene

MGAT5

miRNAs that regulate target gene

hsa-mir-502-3p ; hsa-mir-769-5p ; hsa-mir-181a-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-7847-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-5189-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-3680-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-7850-5p ; hsa-mir-4529-3p ; hsa-mir-4520-2-3p ; hsa-mir-8058 ; hsa-mir-5009-5p ; hsa-mir-1269b ; hsa-mir-1269a ; hsa-mir-3121-5p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-5581-3p ; hsa-mir-1236-3p ; hsa-mir-6845-3p ; hsa-mir-3667-3p ; hsa-mir-877-3p ; hsa-mir-5685 ; hsa-mir-6872-3p ; hsa-mir-4690-3p ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-6768-5p ; hsa-mir-5681a ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-6886-3p ; hsa-mir-938 ; hsa-mir-6505-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-3941 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-629-3p ; hsa-mir-29b-2-5p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-6742-5p ; hsa-mir-92a-2-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-193b-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4695-5p ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-4438 ; hsa-mir-484

Nearest miRNA

hsa-mir-1285-2/Upstream/155017; hsa-mir-10b/Downstream/575611;

Nearest TSS

ENST00000437798/Upstream/27950; ENST00000498093/Downstream/177065;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/90053, chr2-CpG: 147/Downstream/435919

Upstream sequence

GACATGAATGACATGGTGATGAAGATAAACTGCCTTCCCTGTACTGCCCAGGAATGCAATGAGGATTAAGAAGGTGGCTTTTAGCCTGTGTCTATGCCAC

Downstream sequence

ATGGGGAGGATGGTTGCTCCCTGAGGGCAGAAGGCCATTATTAGCAACTGAGTTGGCCAGGAGTGTGTGCCATGCCGGGCTGGGTGTACGGAGCTGTCAA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.