Basic Information
VIS ID
TVIS44029192
Fusion event
HTLV-1-TMEM67 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
94869480/93788076 (Hg38)
End
94869480/93788076 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
TMEM67
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-1227-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-3926 ; hsa-mir-4252 ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-20a-3p ; hsa-mir-1273g-3p ; hsa-mir-8063 ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-6878-3p ; hsa-mir-4512 ; hsa-mir-4775 ; hsa-mir-223-3p ; hsa-mir-4697-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-1304-3p ; hsa-mir-16-1-3p ; hsa-mir-6760-3p ; hsa-mir-1208 ; hsa-mir-32-3p ; hsa-mir-7850-5p ; hsa-mir-6515-5p ; hsa-mir-7977 ; hsa-mir-4443 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6730-3p ; hsa-mir-383-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-5007-3p ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-103a-2-5p ; hsa-mir-8069 ; hsa-mir-758-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-12123/Upstream/758237; hsa-mir-10400/Downstream/127946;
Nearest TSS
ENST00000518652/Upstream/2807; ENST00000523230/Downstream/3134;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/33090, chr8-CpG: 136/Downstream/128214
Upstream sequence
GTATGTATAAATAGAGTATAATACTGATTCAGTTTACATTTTGGTCAAAAGACAGTCTTTTTTTTTTTTTTAAGTTCTAAATAAACCTTTCTCTACATAT
Downstream sequence
AGTCAAGTCTTAATTATTCTTTACTAATAATGGTAAGAGGTGAGTTCTTATGGATCCTGAGTATAAAAAAGTAAGAATGGATTATGTTTTTCAGTAGAAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate