Basic Information
VIS ID
TVIS44029230
Fusion event
HTLV-1-CCDC149 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
NCBI36/hg18
Start
24542424/24931704 (Hg38)
End
24542424/24931704 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
CCDC149
miRNAs that regulate target gene
hsa-mir-488-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4766-5p ; hsa-mir-651-3p ; hsa-mir-3133 ; hsa-mir-548b-3p ; hsa-mir-510-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-494-3p ; hsa-mir-299-3p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-8485 ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6868-3p ; hsa-mir-4635 ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-4796-5p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-600 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-3938 ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-12113/Upstream/411414; hsa-mir-1243/Downstream/3887878;
Nearest TSS
ENST00000502981/Upstream/18750; ENST00000510415/Downstream/48444;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/18449, chr4-CpG: 78/Downstream/98702
Upstream sequence
catcgaattggctagaactagtcacatgaccctaattgcaaaagcactggggaTCAAGCAGGTGGAGGTTATGCAGTGCATATTTTTATGAGCATTATTG
Downstream sequence
TCTTTGCCACTTATGCATCTTCCAGAAAGCCTTCCTGGTTTCCTCTGGCTACAAACAATGTCTCCTGCCTCTGAATTCTGGCAGCACTGTAATATGTTCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate