Basic Information
VIS ID
TVIS44029245
Fusion event
HTLV-1-MAML2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
NCBI36/hg18
Start
95351585/95978773 (Hg38)
End
95351585/95978773 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAML2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-6868-3p ; hsa-mir-6715b-3p ; hsa-mir-3605-3p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-10392/Upstream/1512193; hsa-let-7a-2/Downstream/362665;
Nearest TSS
ENST00000527297/Upstream/53458; ENST00000332349/Downstream/114747;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/54572, chr11-CpG: 75/Downstream/410599
Nearest cancer related gene
MAML2(OG, No orient, 0)
Upstream sequence
ACATTGACACCACAGTTCTGTTTGGATAAATTGGATACTGTATCCTGGAGTTTAGACAGGGAAAAGTGATCCCAATATTTTACTTTCAGGTGTAAGATTT
Downstream sequence
AAAACAAGAATTTGGACCAAAATGTTCATCACTGCAGTTACTTTCTGCTTTCCATTTTTAAGCATGTTATCTTCATGTAGTCCACCTGAACATCAACAGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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