Basic Information
VIS ID
TVIS44029256
Fusion event
HTLV-1-TMEM132C integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
NCBI36/hg18
Start
127617712/128567214 (Hg38)
End
127617712/128567214 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TMEM132C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7156-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-1184 ; hsa-mir-1976 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-141-5p
Nearest miRNA
hsa-let-7i/Upstream/273036; hsa-mir-6763/Downstream/4014783;
Nearest TSS
ENST00000382841/Upstream/299811; ENST00000611714/Downstream/234487;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/151694, chr12-CpG: 21/Downstream/137976
Upstream sequence
TCAAGTTTTCCAGGACCACTCAAGGATAGCCAGTCTTCTAAGACCCCATCCAAATCAGAACATCATAATGTCTCCTTCAAGGAGTGTTTCACACAGACCT
Downstream sequence
ATCTTTATCCAAAAAGGCTGTTTCAATGCAAGAGAAAGAAGTGCCAACCCAAACTCAATTGAAAAAAAGAACCTAGCAAACTAGGAGTAAGCTTGAATTC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate