Basic Information
VIS ID
TVIS44029302
Fusion event
HTLV-1-RAD50 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
NCBI36/hg18
Start
131984518/132620927 (Hg38)
End
131984518/132620927 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
RAD50
miRNAs that regulate target gene
hsa-mir-544a ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-766-5p ; hsa-mir-5093 ; hsa-mir-4261 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-7113-5p ; hsa-mir-5584-5p ; hsa-mir-4496 ; hsa-mir-1252-3p ; hsa-mir-335-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-4753-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-6762-3p ; hsa-mir-604 ; hsa-mir-3160-5p ; hsa-mir-130b-5p ; hsa-mir-1182 ; hsa-mir-1304-3p ; hsa-mir-4524b-3p ; hsa-mir-4639-3p ; hsa-mir-4727-5p ; hsa-mir-4769-3p ; hsa-mir-511-5p ; hsa-mir-6794-3p ; hsa-mir-6817-5p ; hsa-mir-6830-3p ; hsa-mir-7702
Nearest miRNA
hsa-mir-10397/Upstream/255328; hsa-mir-103a-1/Downstream/806669;
Nearest TSS
ENST00000502646/Upstream/2656; ENST00000617259/Downstream/20846;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/63662, chr5-CpG: 77/Downstream/34935
Upstream sequence
tatgcagtattctttcacaataaagtaaactggagacaagaaaaaattataagggaaaatatattttctgttaagtggaaatgaatcatcataaaggtct
Downstream sequence
tcatccttgtcctcttcacattgaagaggaggaggaagaagaggaggggtcagtcttgctgtctcggatggcagaggtggaagaaaatctacataaacat
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate