Basic Information
VIS ID
TVIS44029401
Fusion event
HTLV-1-IRAK1BP1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
NCBI36/hg18
Start
79664462/78898026 (Hg38)
End
79664462/78898026 (Hg38)
Orient
+
Location type
Intronic
Target gene
IRAK1BP1
miRNAs that regulate target gene
hsa-mir-759 ; hsa-mir-892c-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-7703 ; hsa-mir-25-5p ; hsa-mir-196a-3p ; hsa-mir-658 ; hsa-mir-661 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4537 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-451b ; hsa-mir-6501-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p
Nearest miRNA
hsa-mir-10398/Upstream/358717; hsa-mir-1202/Downstream/11414716;
Nearest TSS
ENST00000381078/Upstream/26735; ENST00000606929/Downstream/166;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29987, chr6-CpG: 44/Downstream/12587
Upstream sequence
CTATCATACTCCAGGTTCTGTTGAGAATCTTCGGTAAGTTTAAGCACATCTTTAACTAAGATATTCTTTAAACAAAACTATCCAGTGCTACATTTCATTG
Downstream sequence
AGTGTCATATTAATAATCTCTCCATTTAATTCCTAAGACGGCAAGCCTGTCTTGTTGCTGTTGAGAATGCGTGGCGCAAAGCTCAAGAAGTCTGTAACCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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