Basic Information
VIS ID
TVIS44029444
Fusion event
HTLV-1-UHRF1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
NCBI36/hg18
Start
4866507/4915495 (Hg38)
End
4866507/4915495 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
UHRF1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-146a-5p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-615-3p ; hsa-mir-191-5p ; hsa-mir-221-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7a-5p ; hsa-mir-146b-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-1227/Upstream/144716; hsa-let-7e/Downstream/17192;
Nearest TSS
ENST00000633603/Upstream/5120; ENST00000588337/Downstream/53618;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5026, chr19-CpG: 20/Downstream/1053
Nearest cancer related gene
UHRF1(OG, No orient, 0)
Upstream sequence
ttgttccaataaaacttgatttataaaaacaggTATggcggggcccagtggctcatgattgtaatcccggtgctttgggaggccaaggcaggcggatcac
Downstream sequence
ctgaggtcaggagttctagaacagcgtgccaacatggtgaaaccccgtctctactaaaaatacaaaaattagccagacgtggtggcgcatgtctgtagtt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate