Basic Information
VIS ID
TVIS44029507
Fusion event
HTLV-1-L3MBTL4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
NCBI36/hg18
Start
5964654/5974655 (Hg38)
End
5964654/5974655 (Hg38)
Orient
+
Location type
Intronic
Target gene
L3MBTL4
miRNAs that regulate target gene
hsa-let-7b-5p
Nearest miRNA
hsa-mir-3976/Upstream/133822; hsa-mir-1-2/Downstream/399706;
Nearest TSS
ENST00000575820/Upstream/18554; ENST00000577935/Downstream/50436;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/78405, chr18-CpG: 22/Downstream/309720
Nearest cancer related gene
L3MBTL4(TSG, No orient, 0)
Upstream sequence
CAGACCTGCCAGTTGTGGACAGCGTGTGACCTAGGGCTGCCTTTCCAGTGAAACGACCAAACAGACTTGCGACACGAGGCAGAGCACCGTCTGCTTCCCA
Downstream sequence
TTCCACAGATTAAAAAGAAAAGTATTCagccaggtgcagtggctcacacttgtaatttcagcactttgggaggccaagttgggaggattgcttgaggcca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate