Basic Information
VIS ID
TVIS44029516
Fusion event
HTLV-1-GRK4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
NCBI36/hg18
Start
2979544/3008019 (Hg38)
End
2979544/3008019 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRK4
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-6776-5p ; hsa-mir-7977 ; hsa-mir-143-5p ; hsa-mir-6781-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-3p ; hsa-mir-5693 ; hsa-mir-4279 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-2116-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-122-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-6823-5p ; hsa-mir-340-3p ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-4645-5p ; hsa-mir-4662a-5p ; hsa-mir-4673 ; hsa-mir-4676-5p ; hsa-mir-4684-5p ; hsa-mir-4755-3p ; hsa-mir-4802-3p ; hsa-mir-548c-3p ; hsa-mir-5703 ; hsa-mir-575 ; hsa-mir-6771-3p ; hsa-mir-6827-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-4800/Upstream/757863; hsa-mir-12113/Downstream/2915256;
Nearest TSS
ENST00000502981/Upstream/38850; ENST00000504308/Downstream/14393;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/43732, chr4-CpG: 39/Downstream/33272
Upstream sequence
ttaagcccaagacttcaaggctatagtacgggatgatcaagcctgtgaatagccactgcactccaacctgggcaatgtagcaagaccccatctctaatac
Downstream sequence
aacagaaaaaaagaaaaGAGACCTCAATAAAAGAAGTGTTAACTTCTCACAATGCATACTGATTGACGTAGACTTTTCCATCTGTCAAAATACAATTAGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate