Basic Information
VIS ID
TVIS44029523
Fusion event
HTLV-1-HECW1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
NCBI36/hg18
Start
43310401/43304277 (Hg38)
End
43310401/43304277 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
HECW1
miRNAs that regulate target gene
hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-5692a ; hsa-mir-4422 ; hsa-mir-548c-3p ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p
Nearest miRNA
hsa-mir-1183/Upstream/153283; hsa-mir-10399/Downstream/747489;
Nearest TSS
ENST00000635602/Upstream/55009; ENST00000481031/Downstream/73501;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/54928, chr7-CpG: 65/Downstream/140514
Upstream sequence
GAGCTCTGGATAAAGCTGCCCTGGCCTGTCTCCAAACCCTCCAACCCAGGCCATCCCCACTTCTCCTGTACTGCCTCAGGGATTCCCGGTGCTTCTGCTG
Downstream sequence
GTCCTGCATCCGGACACCTGACCCATCCCAGTGCAGTCCAGGAACCAGGAACTCAATTCGAGCAATTCTGGGCACCAAGCCTAGTGCTTACAAGAATTCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate