Basic Information
VIS ID
TVIS44029568
Fusion event
HTLV-1-ADAMTS9 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
NCBI36/hg18
Start
64568171/64607455 (Hg38)
End
64568171/64607455 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADAMTS9
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-183-3p ; hsa-mir-3613-3p ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-3941 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7g/Upstream/3989585; hsa-mir-12124/Downstream/2618009;
Nearest TSS
ENST00000440867/Upstream/23602; ENST00000485174/Downstream/8695;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/161939, chr3-CpG: 182/Downstream/77956
Nearest cancer related gene
ADAMTS9(TSG, No orient, 0)
Upstream sequence
ctccatcatttttacatctttcacactacctagcagagtgctgtggctaaaataggtacttaatagagctctgtGACTTTATTTGACTTCTAGGAAATTA
Downstream sequence
TCCTGAAGAAATAACTGGAGTTTGCATCAATATTTTTATAAGAGACAAAAAAACTGGACACCACCAAAGTATGCAACAACCAAAAGTTCAATATCACAGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate