Basic Information
VIS ID
TVIS44029648
Fusion event
HTLV-1-LRP1B integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
140814448/140340409 (Hg38)
End
140814448/140340409 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LRP1B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-200c-3p ; hsa-mir-106b-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-128-1/Upstream/4674931; hsa-mir-10b/Downstream/246217;
Nearest TSS
ENST00000437798/Upstream/42440; ENST00000410015/Downstream/17659;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1559329, chr2-CpG: 58/Downstream/1789746
Nearest cancer related gene
LRP1B(TSG, No orient, 0)
Upstream sequence
ATGGTCTTTGAACATGTCTAGCTCCTAAACAGTAAATTGTATAACAGTTTGAAATATTATCCATTCTGGGTAAGTGTGCATTTCATATAGCCTTAAATAC
Downstream sequence
ATATCTATGGTAATTGCTCATTTTTAGGCATTAGTTAGTGAGTGAATAATTTGTTGGTGCTTGGGGTGCTAATTCCGATATTATTCTCCTTCCTTATTTC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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