Basic Information
VIS ID
TVIS44029657
Fusion event
HTLV-1-TCHP integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
NCBI36/hg18
Start
108814978/109892790 (Hg38)
End
108814978/109892790 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TCHP
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-484 ; hsa-mir-92a-3p ; hsa-mir-3149 ; hsa-mir-5095 ; hsa-mir-6872-3p ; hsa-mir-4742-5p ; hsa-mir-4438
Nearest miRNA
hsa-let-7i/Upstream/59354; hsa-mir-1178/Downstream/1411352;
Nearest TSS
ENST00000382841/Upstream/12114; ENST00000537218/Downstream/7474;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/11817, chr12-CpG: 63/Downstream/7385
Nearest cancer related gene
TCHP(TSG, No orient, 0)
Upstream sequence
ACCCCAGCAGAAGGGAATTGGTGCGGGATTTGGGATGGGAACCCTGATGCACTGTAAAGACCATCAGAGTGCTCTGCCCAACTACTCTAAGCCTCAGTGG
Downstream sequence
GGTTACTCTAACTCATACTCCTAGAGACACTGTGAGGATGAAGGTGGTCACCCAGGAACAGGACAATCAAGGTTCAGTAACTGGTAAGCAGGTGTTGGCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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