Basic Information
VIS ID
TVIS44029695
Fusion event
HTLV-1-TBC1D22B integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
NCBI36/hg18
Start
37380328/37304574 (Hg38)
End
37380328/37304574 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TBC1D22B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-122-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-1255b-2-3p ; hsa-mir-6776-3p ; hsa-mir-4803 ; hsa-mir-497-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-5591-3p ; hsa-mir-423-3p ; hsa-mir-7113-5p ; hsa-mir-211-3p ; hsa-mir-4733-3p ; hsa-mir-7845-5p ; hsa-mir-6753-5p
Nearest miRNA
hsa-mir-1236/Upstream/682062; hsa-mir-10398/Downstream/250791;
Nearest TSS
ENST00000381078/Upstream/46419; ENST00000469316/Downstream/49398;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/46650, chr6-CpG: 85/Downstream/49289
Upstream sequence
acatggaagagtctcagaaaccatgaaacagaatgaaagaagccagataccaaaaaatatatatattgtatgattcacattatatggagttaaaaatagg
Downstream sequence
taaagcttatctatggcgatagaaatgagagcaaagtttacctatggtgggaggtgggctgagaatgagcataaggaaacatttccggggtgatggaaat
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate