Basic Information
VIS ID
TVIS44029714
Fusion event
HTLV-1-SLIT3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
NCBI36/hg18
Start
168316047/168956464 (Hg38)
End
168316047/168956464 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
SLIT3
miRNAs that regulate target gene
hsa-mir-218-2-3p ; hsa-mir-218-5p ; hsa-mir-1343-3p ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-214-3p ; hsa-mir-24-3p ; hsa-mir-3074-5p ; hsa-mir-3619-5p ; hsa-mir-3690 ; hsa-mir-4254 ; hsa-mir-4291 ; hsa-mir-4511 ; hsa-mir-6077 ; hsa-mir-646 ; hsa-mir-6783-3p ; hsa-mir-7152-5p ; hsa-mir-7-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10397/Upstream/188209; hsa-mir-10523/Downstream/307137;
Nearest TSS
ENST00000502646/Upstream/73126; ENST00000514811/Downstream/36536;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/376551, chr5-CpG: 94/Downstream/343961
Upstream sequence
AAAACTGTCTACATTTATGTAGGCAATAGTAAGTAAGACTGACACAAAGTATATATGATGAAATATTTAGGTTTATTAAAAAAAATCAAATTACCTTTTA
Downstream sequence
CCTACAATGAGAAGGCTCAACCAGCTGATTCATAAAGAATCACAGAGGGggccaggcatggtggctcacatctgtaatcccagcacattgggaggccaag
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate