Basic Information
VIS ID
TVIS44029799
Fusion event
HTLV-1-CUL7 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
NCBI36/hg18
Start
43127437/43051721 (Hg38)
End
43127437/43051721 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
CUL7
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10398/Upstream/1318111; hsa-mir-10524/Downstream/382821;
Nearest TSS
ENST00000381078/Upstream/3561; ENST00000472792/Downstream/1978;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29949, chr6-CpG: 50/Downstream/1666
Nearest cancer related gene
CUL7(OG, No orient, 0)
Upstream sequence
TGAATGCCCTCGAAAGACATGGGGTGTTCAGAGAGCGTGGCCTGTGCAAACAGTGCTAGCAGAGCACAGCGGCTGTCAAAATCCAGGTGTTTCTCAATGG
Downstream sequence
CTTCTTGTTGGCTCAGTGACAGAAGGATCTGAGTCCGGGTCCCTGTAACCCACACCCCAGTTGGTAACTTCTCCCTAATCTCACCCTTCCTAGAAATCTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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