Basic Information
VIS ID
TVIS44029836
Fusion event
HTLV-1-IRAK3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
NCBI36/hg18
Start
64869898/66189851 (Hg38)
End
64869898/66189851 (Hg38)
Orient
+
Location type
Intronic
Target gene
IRAK3
miRNAs that regulate target gene
hsa-mir-155-3p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-mir-1233-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6883-5p ; hsa-mir-6799-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4755-3p ; hsa-mir-4673 ; hsa-mir-3937 ; hsa-mir-4645-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-383-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4508 ; hsa-mir-6126 ; hsa-mir-3178 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4493 ; hsa-mir-4486 ; hsa-mir-605-3p
Nearest miRNA
hsa-let-7i/Upstream/166125; hsa-mir-1178/Downstream/61231;
Nearest TSS
ENST00000382841/Upstream/594; ENST00000536862/Downstream/67583;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/286, chr12-CpG: 65/Downstream/45374
Upstream sequence
ATGATGTCTTCTGGTCCTTGCAAAATCACCCCAGAACATCATTTTAGTATTGAGACATTTTTAGAACTTTGAGATACTTATCCTTTGGTGTTTTCAATGC
Downstream sequence
ATCCCTAAGCCCCTAACTTAATTACAAGTGAAATGCTAAAGTAAACTACGGTTTGCAATGAACGCGGCTCCTAATTTTCTTAATTAAATCTTATTTACCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate