Basic Information
VIS ID
TVIS44029843
Fusion event
HTLV-1-MTSS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
NCBI36/hg18
Start
125724431/124643009 (Hg38)
End
125724431/124643009 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
MTSS1
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-135a-5p ; hsa-mir-7111-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-33a-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-96-5p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-12123/Upstream/134433; hsa-mir-10400/Downstream/178969;
Nearest TSS
ENST00000518652/Upstream/23530; ENST00000525292/Downstream/30504;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/103729, chr8-CpG: 161/Downstream/84435
Nearest cancer related gene
MTSS1(TSG, No orient, 0)
Upstream sequence
ACGGTGTtaaacctcagttttctcatctgtgaaacaggagcaatgaaacctacttgagccagccattgtgagaactaacaataacagacttagcacatac
Downstream sequence
aataagttctcaatccatggtagctgctattcttCTTTTTCTCTGCATAATTAAGGGGGAAAACTGAGTATCTTTGATCAATAAAATTTGGCAGAGAGAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate