Basic Information
VIS ID
TVIS44029851
Fusion event
HTLV-1-CCDC106 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
NCBI36/hg18
Start
60852525/55649347 (Hg38)
End
60852525/55649347 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CCDC106
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-let-7e-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-4736 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-181d-3p ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-4655-5p
Nearest miRNA
hsa-let-7e/Upstream/261105; hsa-mir-10394/Downstream/2685341;
Nearest TSS
ENST00000633603/Upstream/428; ENST00000592867/Downstream/4799;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/776, chr19-CpG: 290/Downstream/2949
Upstream sequence
GGCACCCCACCTAGACCCACAGATCTTTTACAGTCTGAGCCCCTCTCGGAGAAACTTCGAGGGTGAGCTGAGGGGGTGTGGAGGGACTGGAGTCAGCTGG
Downstream sequence
GAAGCCAAGCCCTGAGTCCCAGGGTGTGACCTGGTCCCCCCACCCTCGCTGTGTCCCTAGAGCCTCCGGAGGCTGCGTCCTCCGCCCTGGCTCTGATGAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate