Basic Information
VIS ID
TVIS44029867
Fusion event
HTLV-1-NOTCH2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p12
Reference genome
NCBI36/hg18
Start
120259914/119915768 (Hg38)
End
120259914/119915768 (Hg38)
Orient
-
Location type
Intronic
Target gene
NOTCH2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-181c-5p ; hsa-mir-326 ; hsa-mir-34a-5p ; hsa-mir-107 ; hsa-mir-155-5p ; hsa-mir-183-5p ; hsa-mir-181a-5p ; hsa-mir-744-5p ; hsa-mir-130b-5p ; hsa-mir-27b-3p ; hsa-mir-196a-5p ; hsa-mir-106a-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-29b-3p ; hsa-mir-6868-3p ; hsa-mir-182-5p ; hsa-mir-3124-3p ; hsa-mir-515-5p ; hsa-mir-519e-5p ; hsa-mir-3942-3p ; hsa-mir-23b-3p ; hsa-mir-205-5p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-6838-5p ; hsa-mir-4274 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-29b-1-5p ; hsa-mir-543 ; hsa-mir-4753-3p ; hsa-mir-5100 ; hsa-mir-6794-3p ; hsa-mir-210-5p ; hsa-mir-4749-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-10b-3p ; hsa-mir-4639-3p ; hsa-mir-146a-5p ; hsa-mir-9-3p ; hsa-mir-9-5p ; hsa-mir-191-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2821040; hsa-mir-1182/Downstream/25934819;
Nearest TSS
ENST00000473358/Upstream/19273; ENST00000608123/Downstream/8137;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/19171, chr1-CpG: 95/Downstream/152966
Nearest cancer related gene
NOTCH2(TSG, No orient, 0)
Upstream sequence
CACACTGGGCAAACGGGCCATTTCTGGAATCTGGTACATGGTGGGCAGGGGGCCCGCAACAGCTGGAGGGCAGGTGGACTGAGGCTGGGGAGCCCCCGCT
Downstream sequence
GGTTGGGCAATACTGCCTTTAGGGATGAGCTGGAAAGTCACAATGGGGGGCAAGGGCTCCCGAGGGGTGGTTATGTGCTTCCCTTCAGGTGGCCTGCTCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate