Basic Information
VIS ID
TVIS44029911
Fusion event
HTLV-1-MORC4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
106086952/106957066 (Hg38)
End
106086952/106957066 (Hg38)
Orient
+
Location type
Intronic
Target gene
MORC4
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-4710 ; hsa-mir-6804-5p ; hsa-mir-6863 ; hsa-mir-6834-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6875-5p ; hsa-mir-4419a ; hsa-mir-3126-5p ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-4739 ; hsa-mir-1249-5p ; hsa-mir-149-3p ; hsa-mir-185-5p ; hsa-mir-3925-5p ; hsa-mir-4306 ; hsa-mir-4311 ; hsa-mir-4644 ; hsa-mir-4728-5p ; hsa-mir-4773 ; hsa-mir-6731-5p ; hsa-mir-6760-5p ; hsa-mir-6785-5p ; hsa-mir-6797-5p ; hsa-mir-6883-5p ; hsa-mir-8085
Nearest miRNA
hsa-let-7f-2/Upstream/317170; hsa-mir-105-1/Downstream/3098263;
Nearest TSS
ENST00000429181/Upstream/14482; ENST00000336387/Downstream/36274;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/229698, chrX-CpG: 109/Downstream/42210
Upstream sequence
CATCAGTGAGTTCTTGTTCCTCTGGAACAGAGCATCTCCTGCAGTACAGAGAATAAATCATCCTTTGGAAAAAAACTGGGTCCTTCACTTTTACCTTTTA
Downstream sequence
ATTTCCTTATAACTATGCAGGTTAACAACTCTCTAACATTACAGAGTTCAGATCCCATTCAAATTATAAAACCTTGTTATATGTAAAGCATGAGAAAGAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate