Basic Information
VIS ID
TVIS44029952
Fusion event
HTLV-1-SACS integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr13
Cytoband
q12.12
Reference genome
NCBI36/hg18
Start
22853653/23381514 (Hg38)
End
22853653/23381514 (Hg38)
Orient
+
Location type
Intronic
Target gene
SACS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-1226-3p ; hsa-mir-424-5p ; hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-106b-5p ; hsa-mir-4465 ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-5697 ; hsa-mir-3159 ; hsa-mir-5684 ; hsa-mir-216b-3p ; hsa-mir-6512-5p ; hsa-mir-302a-5p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-4499/Upstream/2947668; hsa-mir-1267/Downstream/780902;
Nearest TSS
ENST00000623511/Upstream/5971; ENST00000443092/Downstream/37457;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/5888, chr13-CpG: 57/Downstream/84814
Upstream sequence
CGTGGGCAGCATGAAGCGCGCGCACACACACACACAGGCAAACACTCCTACTAGCCTGCACAGGATCAATACACAAGCATGAATTATAGAATAGAGATAT
Downstream sequence
ATACCTTCAGCAAAAAGGGTGTGATCTTACACTTTCTACTTCTTTTCAGTTACTGACAGTCACTTGAGTTCTGCCCTTTATTTTGTTTTGAGGTGCTGTC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate