Basic Information
VIS ID
TVIS44029965
Fusion event
HTLV-1-ATXN7L1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
105211711/105784029 (Hg38)
End
105211711/105784029 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ATXN7L1
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-218-5p ; hsa-mir-5689 ; hsa-mir-605-3p ; hsa-mir-101-5p ; hsa-mir-6882-5p ; hsa-mir-3910 ; hsa-mir-300 ; hsa-mir-381-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-4325 ; hsa-mir-5680 ; hsa-mir-1183 ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-548c-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-4282 ; hsa-mir-135a-5p ; hsa-mir-135b-5p ; hsa-mir-3660 ; hsa-mir-4315 ; hsa-mir-4526 ; hsa-mir-4790-5p ; hsa-mir-8074 ; hsa-mir-889-5p
Nearest miRNA
hsa-mir-10525/Upstream/3312498; hsa-mir-10399/Downstream/8869316;
Nearest TSS
ENST00000635602/Upstream/92392; ENST00000474330/Downstream/92448;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/200626, chr7-CpG: 96/Downstream/92369
Upstream sequence
gtggggtctgtgctaactctgggtagtgtttttttggttcatgtttttttgagacagggtctcactctgttacccagggtggagtgcagtggcaccatca
Downstream sequence
tagctcactgcaacctcaacctcctgggctcaagtgattctcctacctcagcatcctgagtagctgggacaacaggcacatgccaacatgcctggctaat
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate