Basic Information
VIS ID
TVIS44029969
Fusion event
HTLV-1-MGAT4A integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
NCBI36/hg18
Start
98712279/98729384 (Hg38)
End
98712279/98729384 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
MGAT4A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-409-3p ; hsa-mir-376a-5p ; hsa-mir-4423-3p ; hsa-mir-376a-2-5p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-564 ; hsa-mir-3622a-5p ; hsa-mir-5582-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/1931031; hsa-mir-10b/Downstream/2580066;
Nearest TSS
ENST00000437798/Upstream/2503; ENST00000496794/Downstream/864;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/120525, chr2-CpG: 150/Downstream/1035
Upstream sequence
AGAATGTAGTCATACATTTTTAATTAGGGTTTCCCAGCTAATAAGTTTAACTGCACGGCACAAGTGAAGAAACTCTTCGGACAAGAGTAAAACCAAGGAT
Downstream sequence
CTACTCACTCTTCAATTATGAGACATAATTCACAGGCTGGCTTGTAAGACACAGGTGACCCACATTTTTATTAGTGTCCACATTTGCAAAAATTTTAATC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate