Basic Information
VIS ID
TVIS44030035
Fusion event
HTLV-1-HADHB integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
NCBI36/hg18
Start
26349087/26272715 (Hg38)
End
26349087/26272715 (Hg38)
Orient
-
Location type
Intronic
Target gene
HADHB
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-1229-3p ; hsa-mir-99a-5p ; hsa-mir-33a-5p ; hsa-mir-633 ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4720-3p ; hsa-mir-4708-3p ; hsa-mir-4493 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4717-5p ; hsa-mir-3154 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4753-5p
Nearest miRNA
hsa-mir-1301/Upstream/943994; hsa-mir-10b/Downstream/1723652;
Nearest TSS
ENST00000437798/Upstream/11694; ENST00000462301/Downstream/35832;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/27176, chr2-CpG: 87/Downstream/72825
Upstream sequence
taggattacaggcttaaaccactgtgcccggctgatatggtcccatttgtctttgagtgcttccttacttttggcacaaaaaagatggaaattcactttg
Downstream sequence
tactttcttctggacctggtatcagtcatttcttaaaaaaccttttgtccttttaatggggaatggcatttagaaaccaaatctggggccgggtatagtg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate