Basic Information
VIS ID
TVIS44030060
Fusion event
HTLV-1-NDUFS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
NCBI36/hg18
Start
206710233/206137264 (Hg38)
End
206710233/206137264 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
NDUFS1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-221-3p ; hsa-mir-3682-5p ; hsa-mir-218-5p ; hsa-mir-3915 ; hsa-mir-5093 ; hsa-mir-3928-3p ; hsa-mir-4670-3p ; hsa-mir-4330 ; hsa-mir-3688-3p ; hsa-mir-1252-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4428 ; hsa-mir-493-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-5701 ; hsa-mir-552-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-1-3p ; hsa-mir-206 ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-5693 ; hsa-mir-6128 ; hsa-mir-613 ; hsa-mir-6722-5p ; hsa-mir-7151-3p
Nearest miRNA
hsa-mir-10b/Upstream/17004153; hsa-mir-1244-1/Downstream/645970;
Nearest TSS
ENST00000437798/Upstream/4295; ENST00000479587/Downstream/21930;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/51460, chr2-CpG: 94/Downstream/21922
Upstream sequence
ttcacctttaagacatattttggtgaagttactgaatttcaagaatgaTAATCAGaatcccagcactttgggaggccaaggcgagtggaccacaaagtca
Downstream sequence
ggagttggagaccagcctggccaatatggtgaaaccccgtctctactaaaaatacaaaaattagccaggtgtggtggtgcgtgcctgtagtcccagctac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate