Basic Information
VIS ID
TVIS44030110
Fusion event
HTLV-1-TGFB1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
NCBI36/hg18
Start
46531660/41333915 (Hg38)
End
46531660/41333915 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
TGFB1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-29b-3p ; hsa-mir-144-3p ; hsa-mir-633 ; hsa-mir-663a ; hsa-mir-21-5p ; hsa-mir-744-5p ; hsa-mir-211-5p ; hsa-mir-17-5p ; hsa-mir-19b-3p ; hsa-mir-93-5p ; hsa-mir-324-3p ; hsa-mir-122-5p ; hsa-mir-130a-3p ; hsa-mir-422a ; hsa-mir-590-5p ; hsa-mir-675-5p ; hsa-mir-146a-5p ; hsa-mir-574-3p ; hsa-mir-15b-5p ; hsa-mir-29b-1-5p ; hsa-mir-106a-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-10395/Upstream/964008; hsa-let-7e/Downstream/535712;
Nearest TSS
ENST00000633603/Upstream/14182; ENST00000537354/Downstream/8115;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2590, chr19-CpG: 33/Downstream/17427
Nearest cancer related gene
TGFB1(TSG, No orient, 0)
Upstream sequence
ATCCAAGTGACTGTTAGTTCCATTTAGTGCAATACGGTATTGCAGTTATGCAAGAAAATATAAAAATGTCTGCATTTGaaatggggcaaaatcttaatta
Downstream sequence
ccgatgacgctggatgagagtttacgggcattcattatcttcattgcttttgtatacatttgaaattttccataataaaGGAATTTAAATCAGAATAGGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate