Basic Information
VIS ID
TVIS44030193
Fusion event
HTLV-1-RPS6KA2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
NCBI36/hg18
Start
166793194/166459716 (Hg38)
End
166793194/166459716 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPS6KA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-5006-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-6827-5p ; hsa-mir-4755-3p ; hsa-mir-1225-3p ; hsa-mir-1247-3p ; hsa-mir-5587-3p ; hsa-mir-370-5p
Nearest miRNA
hsa-mir-10398/Upstream/7694963; hsa-mir-1913/Downstream/49638;
Nearest TSS
ENST00000381078/Upstream/165; ENST00000455390/Downstream/50594;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/3974, chr6-CpG: 21/Downstream/159126
Nearest cancer related gene
RPS6KA2(TSG, No orient, 0)
Upstream sequence
GACAGAGAAACCTGCTGTGGGGAGGGAAGGATGTTCTTATCACAGACTGCATTGGCCTTGTGGATTACAAGGGATTTCTAAATACTCTGAAATATAGATG
Downstream sequence
GCATAAAATATATTATGTGTAGTATGATAGATACTATGGCATATATAATAACGATGTATTATAGAAAGGTATAGAAAAGGCATAGTTTGAGGTATGAGGG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate