Basic Information
VIS ID
TVIS44030197
Fusion event
HTLV-1-MITF integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p13
Reference genome
NCBI36/hg18
Start
70096162/69964321 (Hg38)
End
70096162/69964321 (Hg38)
Orient
-
Location type
Intronic
Target gene
MITF
miRNAs that regulate target gene
hsa-mir-96-5p ; hsa-mir-182-5p ; hsa-mir-137 ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-218-5p ; hsa-mir-675-5p ; hsa-mir-101-3p ; hsa-mir-2113 ; hsa-mir-147b ; hsa-mir-210-3p ; hsa-mir-6828-5p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-3679-3p ; hsa-mir-513a-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6830-5p ; hsa-mir-4762-5p ; hsa-mir-224-5p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-216a-5p ; hsa-mir-340-5p
Nearest miRNA
hsa-let-7g/Upstream/915286; hsa-mir-12124/Downstream/1577649;
Nearest TSS
ENST00000440867/Upstream/27492; ENST00000641336/Downstream/35229;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/224264, chr3-CpG: 50/Downstream/1100862
Nearest cancer related gene
MITF(OG, No orient, 0)
Upstream sequence
cccccctcggcctcccaaaTAATATTTTTCTTTTATCAGCTCGCATTTAAAACTTTATTTTTGTATTTTTTAACTTATCCTCAGTGTGAACATTAATATC
Downstream sequence
TGTGAGAGACCATCTCTATTTTTCATACATAATCAAAtctataaaacacctaaaaatttatttcacatactgccagtggtacttctcctatactttagaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate