Basic Information
VIS ID
TVIS44030212
Fusion event
HTLV-1-NDRG4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
NCBI36/hg18
Start
57103297/58511892 (Hg38)
End
57103297/58511892 (Hg38)
Orient
+
Location type
Intronic
Target gene
NDRG4
miRNAs that regulate target gene
hsa-mir-3145-3p ; hsa-mir-4789-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1299 ; hsa-mir-3120-3p ; hsa-mir-3613-3p ; hsa-mir-4261 ; hsa-mir-545-3p ; hsa-mir-548p ; hsa-mir-6128 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-1225/Upstream/739540; hsa-mir-11401/Downstream/8690429;
Nearest TSS
ENST00000527434/Upstream/1181; ENST00000468223/Downstream/3587;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10200, chr16-CpG: 129/Downstream/3231
Nearest cancer related gene
NDRG4(TSG, No orient, 0)
Upstream sequence
AGCCAACTTGACCCCTCTCATCCCACTCCCGGCGGCCCAGGCACAGAAGGGCAGGGCCATAGGGAGGGAGATTCGCTACGGATCCAGGCCATTCCTGGGT
Downstream sequence
GAGCCCTTGGGCAGGCATGTTTGGAGATGAGAGAGGCTTCGAGAGGGTGGGTGCTGGGCCACAGGGGTGCGGGGCCAGCTCAGGCACTGGCGTGGGAGCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate