Basic Information
VIS ID
TVIS44030245
Fusion event
HTLV-1-PRKCH integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
NCBI36/hg18
Start
60969703/61433232 (Hg38)
End
60969703/61433232 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
PRKCH
miRNAs that regulate target gene
hsa-mir-376c-3p ; hsa-mir-432-5p ; hsa-mir-376a-3p ; hsa-mir-493-3p ; hsa-mir-4531 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-3938 ; hsa-mir-3675-3p ; hsa-mir-216b-5p ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-208a/Upstream/784521; hsa-mir-1185-1/Downstream/2661792;
Nearest TSS
ENST00000550708/Upstream/42538; ENST00000557473/Downstream/9326;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/110483, chr14-CpG: 112/Downstream/261897
Upstream sequence
GTTGGATTTCAAATTAGTCTGTTTACAGTGAGCAACAGTACAGCAGTTTTAAAAATCATGTTGAATCAGAAACATGAAGAAGGCAGCAGAGCTTTCTCTC
Downstream sequence
CACCATGCACTTGGAGAAGGAAATGACTCGGCAGCATACTCCTCATGGCTAATATCCTTTAAGATTTTTCCAAAATCATGAAACCAGAACTTGAGAGCTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate