Basic Information
VIS ID
TVIS44030259
Fusion event
HTLV-1-UHRF1BP1L integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q23.1
Reference genome
NCBI36/hg18
Start
99057244/100139335 (Hg38)
End
99057244/100139335 (Hg38)
Orient
-
Location type
Intronic
Target gene
UHRF1BP1L
miRNAs that regulate target gene
hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-514a-5p ; hsa-mir-5004-3p ; hsa-mir-629-3p ; hsa-mir-4279 ; hsa-mir-4320 ; hsa-mir-2116-3p ; hsa-mir-3121-5p ; hsa-mir-6865-3p ; hsa-mir-7977 ; hsa-mir-6866-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6089 ; hsa-mir-433-5p
Nearest miRNA
hsa-let-7i/Upstream/2143887; hsa-mir-1178/Downstream/50549;
Nearest TSS
ENST00000382841/Upstream/46371; ENST00000550886/Downstream/3489;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/154206, chr12-CpG: 81/Downstream/2803
Upstream sequence
TTCTCAAATAGTTTAGCATTGAGTTAAAGAATCTGTTAATCTCTTAAGAACAATTCCTCTTCCATACTTTCCCAACATACCAGCTTCTCAAGTCCCTTCA
Downstream sequence
TCCAGGCAAAGATGGTTTTAATCTTGCAACTGCACTATATTTCAACCTCAAGGCTAAAAATGAGAGCTCTTTCTCATGTTGGTTCACAGTCTTCCTCCTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate