Basic Information
VIS ID
TVIS44030275
Fusion event
HTLV-1-CCND3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
NCBI36/hg18
Start
42048617/41972901 (Hg38)
End
42048617/41972901 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
CCND3
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-195-5p ; hsa-mir-138-5p ; hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-27b-3p ; hsa-let-7b-5p ; hsa-mir-503-5p ; hsa-mir-28-5p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-497-5p ; hsa-mir-218-5p ; hsa-mir-7106-5p ; hsa-mir-6722-3p ; hsa-mir-765 ; hsa-mir-6836-5p ; hsa-mir-1909-3p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-15b-5p ; hsa-mir-15b-3p
Nearest miRNA
hsa-mir-10398/Upstream/239291; hsa-mir-10524/Downstream/1461641;
Nearest TSS
ENST00000381078/Upstream/31053; ENST00000412701/Downstream/57152;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/30928, chr6-CpG: 48/Downstream/75604
Upstream sequence
atctcagaagttcaagaccagcctgggcaacagagtgaaaccccatctctacaaaaaatTtacatatatatatatatatttaaaaattaaaaatatatat
Downstream sequence
atatatGACTGAGTTGGAGAGGGGCAGAAGGGGCAAGGGACATGGGATGGCCAGATGGTGTGATTCCAGATGAATGCACATGGCTAAGCTGGGGAAGAGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate