Basic Information
VIS ID
TVIS44030289
Fusion event
HTLV-1-CLDND1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
NCBI36/hg18
Start
99723365/98521831 (Hg38)
End
99723365/98521831 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLDND1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-92a-3p ; hsa-mir-4528 ; hsa-mir-5096 ; hsa-mir-584-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-5579-5p ; hsa-mir-4670-3p ; hsa-mir-154-5p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-6515-5p ; hsa-mir-516b-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-518c-5p ; hsa-mir-4267 ; hsa-mir-1178-5p ; hsa-mir-335-3p ; hsa-mir-4742-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-1279 ; hsa-mir-140-3p ; hsa-mir-4423-3p ; hsa-mir-548an ; hsa-mir-548u ; hsa-mir-556-3p ; hsa-mir-5582-5p ; hsa-mir-651-3p ; hsa-mir-6809-5p ; hsa-mir-6830-5p ; hsa-mir-7161-5p
Nearest miRNA
hsa-let-7g/Upstream/2161792; hsa-mir-12124/Downstream/1442483;
Nearest TSS
ENST00000440867/Upstream/548; ENST00000502999/Downstream/683;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/549266, chr3-CpG: 57/Downstream/734
Upstream sequence
ACACATTACAGATACAAACAATAGACATGCCCATGGTCAGCAGTGTACCGTGCACACATTTTAAATTACAGACTGAATTTTTGCACGAGCTGCAGAGGAT
Downstream sequence
TAAGTGTTCTGGGTTTGAGTGTTAAAAAGGCACAGGAAAAAGAAGCAGTGGAAATTGGCTTCTCCCAGTTTCCTCTGAAGAGGGAAGCCTCCTAAAACAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate