Basic Information
VIS ID
TVIS44030309
Fusion event
HTLV-1-IKZF1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
p12.2
Reference genome
NCBI36/hg18
Start
50388914/50353722 (Hg38)
End
50388914/50353722 (Hg38)
Orient
-
Location type
Intronic
Target gene
IKZF1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1183/Upstream/5471922; hsa-mir-10399/Downstream/6602063;
Nearest TSS
ENST00000635602/Upstream/26073; ENST00000492119/Downstream/13943;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48799, chr7-CpG: 79/Downstream/46146
Nearest cancer related gene
IKZF1(TSG, No orient, 0)
Upstream sequence
CAGCCCCCGAGGCTGTGAAGAGCCCAGGGGCCAGTAGATGCCACTTTTGCTCCAGGAAGAATCTTCAACTGTGTCCTTTTTATTCAAGGGGCTCTCTTTT
Downstream sequence
CAGCGAATCTCTAGATGTACTAGTCACAAACACTCGCATTTATTAAAATGTATCCATGATCCCACAATCCTTTTACATATTTCTCTCCAGGAGTATCACA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate