Basic Information
VIS ID
TVIS44030319
Fusion event
HTLV-1-ZBTB16 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
NCBI36/hg18
Start
113493583/114117651 (Hg38)
End
113493583/114117651 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
ZBTB16
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-5580-3p ; hsa-mir-190a-3p ; hsa-mir-301b-3p ; hsa-mir-3145-3p ; hsa-mir-186-3p ; hsa-mir-5685 ; hsa-mir-4699-3p ; hsa-mir-4690-3p ; hsa-mir-3908 ; hsa-mir-330-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6749-3p ; hsa-mir-452-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-4469 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-5088-3p ; hsa-mir-5193 ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-1306-5p ; hsa-mir-5011-5p ; hsa-mir-6778-3p ; hsa-mir-3162-3p ; hsa-mir-361-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10392/Upstream/667563; hsa-let-7a-2/Downstream/4526349;
Nearest TSS
ENST00000527297/Upstream/53239; ENST00000545851/Downstream/63115;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34534, chr11-CpG: 24/Downstream/81490
Nearest cancer related gene
ZBTB16(TSG, No orient, 0)
Upstream sequence
aaggagttggttgagactcctgaggttttggcttggataactggtggatggtgggaatagagaaggagttctgggtggaaaaccaaagtctctcttttgg
Downstream sequence
acatggagtttgagGAGGTCTTGGAAAAACTATATAGAGGTAGTCTGCAATATTTGCAGTGGGTCTTGAAGGAAAGATATTTTGATAAGCAGAAGTTGTC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate